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DECORATION
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The extract "Trejos devynerios"
was awarded as the best product of the year in Lithuania and
decorated with the medal in 1999.
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THE QUALITY OF EXTRACT
The quality of extract is established by the article
of Farmakopeja FS 112: 200.
PURENESS
| Dry remnant |
Not less than 1.8 %. According to Ph. Eur. 1997:0792. |
| Relative density |
0,935 - 0,960 ( Ph. Eur. 1997, 2.2.5). |
| Etanol |
Not less than 37 %. According to Ph. Eur. 1997,
2.9.10. |
| Heavy metals |
Not more than 0.01 % (Ph. Eur. 1997, 2.4.8). |
| The number of bitter taste |
Not less than 2900 (The methodology adapted to
FP V and ZLPN I. L.). |
DETERMINATION OF QUANTITY
Determined using the method of high-pressure liquid
chromatography.
Adapting this method to the length of radio wave 254 nm, 9 characteristic
spikes are obtained, with the length of 289 nm, 7 ones. The area
of spikes has to be not less than the data in the table.
|
Length of radio wave, nm
|
Duration of retention, min
|
Minimal area of spike
|
|
1
|
2
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3
|
|
254
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5,8
|
645000
|
|
254
|
6,0
|
3565000
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|
254
|
6,8
|
280000
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|
254
|
7,3
|
292000
|
|
254
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7,7
|
538000
|
|
254
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8,1
|
225000
|
|
254
|
8,7
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360000
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|
254
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9,1
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680000
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254
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9,6
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281000
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289
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5,8
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692000
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289
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6,0
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434000
|
|
289
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6,8
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353000
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|
289
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7,7
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308000
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|
289
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8,1
|
394000
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|
289
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8,7
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1037000
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|
289
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9,6
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338000
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When the length of radio wave is 254 nm, rutin,
izokvercitin and kvercitin are determined, and when the length of
the radio wave is 289 nm, phrangulin and ? - tujon are determined.
The amount of those materials should be not less than it is specified
in the table (mg/ ml of the extract).
|
Length of radio wave, nm
|
Material
|
Duration of retention of spike, min
|
Minimal quantity, mg/ ml
|
|
254
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Rutin
|
5,8
|
0,035
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254
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Izokvercitin
|
6,0
|
0,16
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|
254
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Kvercitin
|
7,7
|
0,02
|
|
289
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Phrangulin
|
9,1
|
0,0028
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|
289
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a - tujon
|
9,6
|
4,2
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MICROBIAL CONTAMINATION
1ml of the extract should contain not more than
104 aerobic bacterium and not more than 102 funguses, enterobacterium
and other negative bacterium. It shouldn't contain Staphhhylococcus
aureus, Salmonella and Escherichia coli. According to Ph. Eur. 1997,
2.6.12, 5.1.3, and 5.1.4 requirements.
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QUALITY
OF ROW MATERIAL
- Populi gemmae (FS -338:1999, BHPh. 1996)
- Capsici fructus (DAB 1998, USP 23, BHPh. 1996)
- Caryophylli flores (DAB 10, BHP 96, Ph. Eur. 01\2002:0376)
- Quercus cortex (Ph. Eur. 01\2002:1887, SSSR
VF XI-3 2 t.)
- Calendulae flores (FS 305:1999, Ph. Eur. 01\2002:1297,
SSSR VF XI-5 2 t.)
- Lauri folia (Martindale 31, HAB 34)
- Menthae folia (FS 306:1999)
- Anethi fructus (FS 311:1999, SSSR VF XI-29 2
t.)
- Crataegi fructus (Ph. Eur. 01\2002:1220)
- Artemisiae absinthii herba (Ph. Eur. 01\2002:1380)
- Piperis aromatici fructus (ÖAB 9, HAB 34)
- Levistici radices (DAB 1997, Ph. Eur. 01\2002:1233)
- Valerianae rhizomata cum radicibus (Ph. Eur. 01\2002:0453)
- Lupuli strobulus (Ph. Eur. 01\2002:1222)
- Aurantii pericarpium (DAB 1997)
- Frangulae cortex (Ph. Eur. 01\2002:0025)
- Salicis cortex (DAB 1997, Ph. Eur. 01\2002:1583,
BHPh. 1996)
- Carvi fructus (Ph. Eur. 01\2002:1080)
- Betulae gemmae seu Betulae folium (FS 321:1999, Ph. Eur.
01\2002:1174, SSSR VF XI-41 2 t.)
- Filipendulae herba (FS 199 -96, BHPh. 1996)
- Hyperici herba (Ph. Eur. 01\2002:1438)
- Hyssopi herba (DAB 6, BHPh. 1996)
- Millefolii herba (Ph. Eur. 01\2002:1382)
- Serpylli herba seu Thymi herba (FS 318:1999,
Ph. Eur. 01\2002:0865, BHPh. 1996)
- Tormentillae rhizomata (Ph. Eur. 01\2002:1478)
- Sorbi fructus (FS 315:1999, SSSR VF XI-39 2
t.)
- Rosae fructus (Ph. Eur. 01\2002:1510)
- Ethanolum 40 % (Ph. Eur. 1997:1317)
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